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Ecotoxicological information

Toxicity to soil macroorganisms except arthropods

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Endpoint:
toxicity to soil macroorganisms except arthropods: long-term
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
QSAR prediction: S EPA accepted QSAR method for chemicals properties assessment.
Qualifier:
according to
Guideline:
other: QSAR
Principles of method if other than guideline:
ECOSAR Program (v1.00)
GLP compliance:
no
Remarks:
not applicable to QSAR models
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
other: earthworm
Animal group:
other: QSAR model
Study type:
other: QSAR
Substrate type:
other: QSAR
Limit test:
no
Total exposure duration:
14 d
Test temperature:
not applicable. QSAR model
pH:
not applicable. QSAR model
Moisture:
not applicable. QSAR model
Details on test conditions:
-Name of test material (as cited in study report:Potassium oxide
CAS Number: 12136-45-7
SMILES : KOK
CHEM : Potash (potassium oxide)
MOL FOR: O1 K2
MOL WT : 94.20
Wat Sol: 1E+006 (mg/L, EPISuite WSKowwin v1.43 Estimate)

Reference substance (positive control):
no
Duration:
14 d
Dose descriptor:
LC50
Effect conc.:
887.517 mg/kg soil ww
Nominal / measured:
not specified
Conc. based on:
not specified
Basis for effect:
not specified
Remarks on result:
other: 1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
Details on results:
LC50 (14-day, earthworm)= 887.517 mg/L (ppm)
1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
LC50 (14-day, earthworm)= 887.517 mg/kg soil dw
Reported statistics and error estimates:
US EPA accepted QSAR method for chemicals properties assessment.

Overview of QSARs estimations on toxicity of  Dipotassium oxide/Potassium oxide to soil macroorganisms

Method

 

Results

Remarks

Reference

QSAR

estimate

LC50 (14-day, earthworm)= 887.517mg/L (ppm)

 

 

Reliable withrestrictions,

QSAR estimated data

ECOSAR Program (v1.00)

 

 

LC50 (14-day, earthworm)= 887.517 mg/kg soil dw

Validity criteria fulfilled:
yes
Remarks:
US EPA accepted QSAR method for chemicals properties assessment.
Conclusions:
LC50 (14-day, earthworm)= 887.517 mg/L (ppm)
1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
LC50 (14-day, earthworm)= 887.517 mg/kg soil dw
Executive summary:

The ECOSAR QSAR model predicts that 14-day, LC50 (14-day, earthworm) would to be 887.517 mg/L (ppm).

1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.

LC50 (14-day, earthworm)= 887.517 mg/kg soil dw

Endpoint:
toxicity to soil macroorganisms except arthropods: long-term
Type of information:
other: Published data
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation
Qualifier:
no guideline followed
Principles of method if other than guideline:
Test substance was added to fresh pine litter substrate. pH and conductivity was measured during 6 months. At regular times the enchytraeids are counted both in the controls and in the test samples. Toxicity was estimated by calcuting the regression equation between reproduction number and pH or conductivity.
GLP compliance:
not specified
Analytical monitoring:
not specified
Details on sampling:
- Concentrations: 0, 500, 1000, 1500, 2000, 2500, 3000, 3500, 4000, 4500, 5000 mg/l
Vehicle:
no
Test organisms (species):
Enchytraeus sp.
Animal group:
annelids
Details on test organisms:
TEST ORGANISM
- Source: Rijksuniversiteit Gent
Study type:
laboratory study
Substrate type:
artificial soil
Limit test:
no
Total exposure duration:
180 d
pH:
7.3 (init.) - 6.3 (fin.)
Moisture:
humidity was adjusted weekly with rainwater
Details on test conditions:
TEST SYSTEM
- Amount of soil or substrate: 3 g/l
- No. of replicates per treatment group:4


SOURCE AND PROPERTIES OF SUBSTRATE (if soil)
-Composition (if artificial substrate): fresh pine substrate
- pH=4.4

EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : reproduction
Nominal and measured concentrations:
- Nominal concentrations: 0, 500, 1000, 1500, 2000, 2500, 3000, 3500, 4000, 4500, 5000 mg/l
Reference substance (positive control):
not specified
Duration:
180 d
Dose descriptor:
EC50
Effect conc.:
850 other: mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
other: population density
Duration:
180 d
Dose descriptor:
other: EC92
Effect conc.:
3 000 other: mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
other: population density
Details on results:
The values of EC50 and EC92 are calculated using the regression given in the method. The enchytraeid population was >95% Cognetia sphagnetorum.

The values of EC50 and EC92 are calculated using the regression given in the method. The enchytraeid population was >95% Cognetia sphagnetorum.

Validity criteria fulfilled:
not specified
Conclusions:
180d EC50 = 850 and EC92 = 3000 mg/l for the enchytraeid population in fresh pine substrate.
When Potassium oxide is hydrated is produced Potassium hydroxide. Therefore, the health effects of Potassium hydroxide need to be considered in the assessment of Potassium oxide

Description of key information

180d LE50 = 850 and EC92 = 3000 mg/l for the enchytraeid population in fresh pine substrate.
The ECOSAR QSAR model predicts that 14-day, LC50 (14-day, earthworm) would to be 887.517 mg/L (ppm).
1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
LC50 (14-day, earthworm)= 887.517 mg/kg soil dw

Key value for chemical safety assessment

Short-term EC50 or LC50 for soil macroorganisms:
850 mg/kg soil dw
Long-term EC10, LC10 or NOEC for soil macroorganisms:
170 mg/kg soil dw

Additional information

180d EC50 = 850 and EC92 = 3000 mg/l for the enchytraeid population in fresh pine substrate.

The ECOSAR QSAR model predicts that 14-day, LC50 (14-day, earthworm) would to be 887.517 mg/L (ppm).

1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.

LC50 (14-day, earthworm)= 887.517 mg/kg soil dw