Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 235-227-6 | CAS number: 12136-45-7
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- other: Human observational study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Perforation of nasal septum due to button battery lodging in nose
- Author:
- Fernando P
- Year:
- 1 987
- Bibliographic source:
- British Med. J., 294, 742-743.
Materials and methods
- Study type:
- poisoning incident
- Endpoint addressed:
- skin irritation / corrosion
- Principles of method if other than guideline:
- A 4-year old boy who had a button battery lodged in his nose for appr. 24 hrs had local tissue corrosion, with a small perforation, caused presumably by the 25% KOH electrolyte.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Potassium hydroxide
- EC Number:
- 215-181-3
- EC Name:
- Potassium hydroxide
- Cas Number:
- 1310-58-3
- Molecular formula:
- HKO
- IUPAC Name:
- potassium hydroxide
- Details on test material:
- - Name of test material (as cited in study report): button battery containing 25% KOH electrolyte
Constituent 1
Method
- Type of population:
- general
- Subjects:
- A 4-year old boy
- Ethical approval:
- not applicable
- Route of exposure:
- dermal
- Reason of exposure:
- accidental
- Exposure assessment:
- estimated
- Details on exposure:
- A 4-year old boy who had a button battery lodged in his nose for appr. 24 hrs had local tissue corrosion, with a small perforation, caused presumably by the 25% KOH electrolyte.
Results and discussion
- Results of examinations:
- A 4-year old boy who had a button battery lodged in his nose for appr. 24 hrs had local tissue corrosion, with a small perforation, caused presumably by the 25% KOH electrolyte.
Applicant's summary and conclusion
- Conclusions:
- indication of potassium hydroxide causing tissue corrosion.
- Executive summary:
The potential for corrosive alkali injury from batteries is in fact dependent on their electrical properties, by the progressive electrolysis of the battery casing, in the area of the seal. Moreover, it is thought that burns to the esophagus could be due to the low-voltage DC producing an electrolysis with an increase of pH. Battery ingestions in the UK and the USA are reviewed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
