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Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
other: Published data
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Principles of method if other than guideline:
Diatoms were cultured in synthetic dilution water under controlled conditions. Tests were made by putting standard inoculum of cells in each of the
150 ml Erlenmeyer flasks, and comparing the number of cells produced at the end of a 5-day period. A graded series of test concentrations were used.
GLP compliance:
not specified
Analytical monitoring:
yes
Vehicle:
yes
Details on test solutions:
Diatoms were cultured in synthetic dilution water under controlled conditions. Tests were made by putting standard inoculum of cells in each of the
150 ml Erlenmeyer flasks, and comparing the number of cells produced at the end of a 5-day period. A graded series of test concentrations were used.
Test organisms (species):
Nitscheria linearis
Details on test organisms:
Nitscheria linearis (diatom)
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
120 h
Hardness:
10 mg/L CaCO3
Test temperature:
22 °C
Dissolved oxygen:
5 to 9 mg/L
Duration:
120 h
Dose descriptor:
EC50
Effect conc.:
1 337 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth rate
Details on results:
Toxicity to aquatic algae and cyanobacteria was determined with Nitscheria linearis (diatom) and was determined as 120h-EC50 = 1337mg/L
Validity criteria fulfilled:
not specified
Conclusions:
Toxicity to aquatic algae and cyanobacteria was determined with Nitscheria linearis (diatom) and was determined as 120h-EC50 = 1337mg/L
Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
QSAR prediction: US EPA accepted QSAR method for chemicals properties assessment.
Qualifier:
according to
Guideline:
other: QSAR model
Principles of method if other than guideline:
ECOSAR Program(v1.00)
GLP compliance:
no
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
other: Green Algae
Details on test organisms:
QSAR model-Green Algae
Test type:
other: QSAR model
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h
Test temperature:
not applicable. QSAR model
pH:
not applicable. QSAR model
Dissolved oxygen:
not applicable. QSAR model
Salinity:
not applicable. QSAR model
Nominal and measured concentrations:
not applicable. QSAR model
Details on test conditions:
-Name of test material (as cited in study report:Potassium oxide
CAS Number: 12136-45-7
SMILES : KOK
CHEM : Potash (potassium oxide)
MOL FOR: O1 K2
MOL WT : 94.20
Values used to Generate ECOSAR Profile

Log Kow: -1.380 (EPISuite Kowwin v1.68 Estimate)
Wat Sol: 1E+006 (mg/L, EPISuite WSKowwin v1.43 Estimate)

Reference substance (positive control):
no
Duration:
96 h
Dose descriptor:
EC50
Effect conc.:
1 368.296 mg/L
Nominal / measured:
not specified
Conc. based on:
not specified
Basis for effect:
not specified
Duration:
30 d
Dose descriptor:
NOEC
Effect conc.:
178.832 mg/L
Nominal / measured:
not specified
Conc. based on:
not specified
Basis for effect:
not specified
Remarks on result:
other: NOEC cited as a ChV value
Details on results:
Green Algae, 96-hr EC50 =1368.296 mg/L (ppm)
Green Algae, 30-day, NOEC cited as a ChV value = 178.832 mg/L(ppm)

Overview of QSARs estimations on aquatic toxicity of Dipotassium oxide/Potassium oxide to Green algae

 

Method

 

Results

Remarks

Reference

QSAR

estimate

Green Algae, 96-hr EC50 =1368.296 mg/L (ppm)

Green Algae, 30-day, NOEC cited as a ChV value = 178.832 mg/L(ppm)

 

Reliable with restrictions,

QSAR estimated data

ECOSAR Program (v1.00)

 Green Algae, 96-hr EC50 =1368.296 mg/L (ppm)

Green Algae, 30-day, NOEC cited as a ChV value = 178.832 mg/L(ppm)

Validity criteria fulfilled:
yes
Remarks:
method for chemicals properties assessment.
Conclusions:
Green Algae, 96-hr EC50 =1368.296 mg/L (ppm)
Green Algae, 30-day, NOEC cited as a ChV value = 178.832 mg/L(ppm)
Executive summary:

The ECOSAR QSAR model predicts that 30-day, NOEC cited as a ChV value would to be 178.832 mg/L (ppm) Green Algae.

The ECOSAR QSAR model predicts that 96-hr EC50 value would to be 1368.296 mg/L (ppm) for Green Algae.

Description of key information

Toxicity to aquatic algae and cyanobacteria was determined with Nitscheria linearis (diatom) and was determined as 120h-EC50 = 1337 mg/L
The ECOSAR QSAR model predicts that 30-day, NOEC cited as a ChV value would to be 178.832 mg/L (ppm) Green Algae.
The ECOSAR QSAR model predicts that 96-hr EC50 value would to be 1368.296 mg/L (ppm) for Green Algae.
 
The available data for saltwater algae and cyanobacteria are limited and to obtaine the value for PNECs for saltwaters is taken account a assesment factor 10 to extrapolate to EC50/NOEC following the “Guidance on Information Requirement and Chemical Safety Assessment R.10: Characterisation of dose [concentration]- response for environment”and “Table R.10-5 Assessment factors proposed for deriving PNEC water for saltwater for different data sets”, to account for the possibility that greater taxonomic diversity in the marine environment makes it likely that some marine taxa may be more sensitive than the most sensitive freshwater taxa

Key value for chemical safety assessment

EC50 for freshwater algae:
1 337 mg/L
EC50 for marine water algae:
133.7 mg/L
EC10 or NOEC for freshwater algae:
178.832 mg/L
EC10 or NOEC for marine water algae:
17.88 mg/L

Additional information

Toxicity to aquatic algae and cyanobacteria was determined with Nitscheria linearis (diatom) and was determined as 120h-EC50 = 1337 mg/L

The ECOSAR QSAR model predicts that 30-day, NOEC cited as a ChV value would to be 178.832 mg/L (ppm) Green Algae.

The ECOSAR QSAR model predicts that 96-hr EC50 value would to be 1368.296 mg/L (ppm) for Green Algae.

 

The available data for saltwater algae and cyanobacteria are limited and to obtaine the value for PNECs for saltwaters is taken account a assesment factor 10 to extrapolate to EC50/NOEC following the “Guidance on Information Requirement and Chemical Safety Assessment R.10: Characterisation of dose [concentration]- response for environment”and “Table R.10-5 Assessment factors proposed for deriving PNEC water for saltwater for different data sets”, to account for the possibility that greater taxonomic diversity in the marine environment makes it likely that some marine taxa may be more sensitive than the most sensitive freshwater taxa