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Ecotoxicological information

Toxicity to aquatic plants other than algae

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Reference
Endpoint:
toxicity to aquatic plants other than algae
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
QSAR prediction: US EPA accepted QSAR method for organic chemicals properties assessment.
Qualifier:
according to
Guideline:
other: QSAR
Principles of method if other than guideline:
ECOSAR Program(v1.00)
GLP compliance:
no
Remarks:
not applicable to QSAR models
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
other: QSAR model
Test type:
other: QSAR model
Water media type:
freshwater
Limit test:
no
Total exposure duration:
30 d
Hardness:
not applicable. QSAR model
Test temperature:
not applicable. QSAR model
pH:
not applicable. QSAR model
Dissolved oxygen:
not applicable. QSAR model
Salinity:
not applicable. QSAR model
Details on test conditions:
-Name of test material (as cited in study report:Potassium oxide
CAS Number: 12136-45-7
SMILES : KOK
CHEM : Potash (potassium oxide)
MOL FOR: O1 K2
MOL WT : 94.20
Values used to Generate ECOSAR Profile

Log Kow: -1.380 (EPISuite Kowwin v1.68 Estimate)
Wat Sol: 1E+006 (mg/L, EPISuite WSKowwin v1.43 Estimate)



Reference substance (positive control):
no
Duration:
96 h
Dose descriptor:
EC50
Effect conc.:
1 368.296 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
other: (Q)SAR prediction
Duration:
30 d
Dose descriptor:
NOEC
Effect conc.:
178.832 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
other: (Q)SAR prediction
Details on results:
A 96 h LC50 value of 1368.296 mg/L has been calculated for the effects of the test substance on the mortality of the Green Algae and Aquatic plants. This result signifies that the test substance is not expected to be toxic .
A reliable 96 h LC50 value of 1368.296 mg/L has been calculated for the effects of the test substance towards Green Algae and Aquatic plants. Therefore the test substance has been predicted to be non toxic.

A NOEC value of 178.832 mg/L has been calculated for the effects of the test substance on the mortality of the Green Algae and Aquatic plants. This result signifies that the test substance is not expected to be toxic.
A reliable NOEC value of 178.832 mg/L has been calculated for the effects of the test substance towards Green Algae and Aquatic plants. Therefore the test substance has been predicted to be non toxic.

Overview of QSARs estimations on aquatic toxicity of  Dipotassium oxide/Potassium oxide

to algae and aquatic plants 

Method

 

Results

Remarks

Reference

QSAR

estimate

Green Algae and Aquatic plants,96-hr EC50 = 1368.296  mg/L (ppm)

 

Green Algae and Aquatic plants, 30-day, ChV (chronic value) =178.832 mg/L(ppm)

 

 

Reliable withrestrictions,

QSAR estimated data

ECOSAR Program (v1.00)

 

  

 

Green Algae and Aquatic plants,96-hrEC50 = 1368.296 mg/L (ppm)

Green Algae and Aquatic plants, 30-day, ChV (chronic value) =178.832 mg/L(ppm)

Validity criteria fulfilled:
yes
Remarks:
US EPA accepted QSAR method for organic chemicals properties assessment.
Conclusions:
A 96 h LC50 value of 1368.296 mg/L has been calculated for the effects of the test substance on the mortality of the Green Algae and Aquatic plants. This result signifies that the test substance is not expected to be toxic .
A reliable 96 h LC50 value of 1368.296 mg/L has been calculated for the effects of the test substance towards Green Algae and Aquatic plants. Therefore the test substance has been predicted to be non toxic.

A NOEC value of 178.832 mg/L has been calculated for the effects of the test substance on the mortality of the Green Algae and Aquatic plants. This result signifies that the test substance is not expected to be toxic.
A reliable NOEC value of 178.832 mg/L has been calculated for the effects of the test substance towards Green Algae and Aquatic plants. Therefore the test substance has been predicted to be non toxic.
Executive summary:

A 96 h LC50 value of 1368.296 mg/L has been calculated for the effects of the test substance on the mortality of the Green Algae and Aquatic plants. This result signifies that the test substance is not expected to be toxic .

A reliable 96 h LC50 value of 1368.296 mg/L has been calculated for the effects of the test substance towards Green Algae and Aquatic plants. Therefore the test substance has been predicted to be non toxic.

A NOEC value of 178.832 mg/L has been calculated for the effects of the test substance on the mortality of the Green Algae and Aquatic plants. This result signifies that the test substance is not expected to be toxic.

A reliable NOEC value of 178.832 mg/L has been calculated for the effects of the test substance towards Green Algae and Aquatic plants. Therefore the test substance has been predicted to be non toxic.

 

Description of key information

A 96 h LC50 value of 1368.296 mg/L has been calculated for the effects of the test substance on the mortality of the Green Algae and Aquatic plants. This result signifies that the test substance is not expected to be toxic .
A reliable 96 h LC50 value of 1368.296 mg/L has been calculated for the effects of the test substance towards Green Algae and Aquatic plants. Therefore the test substance has been predicted to be non toxic.
A NOEC value of 178.832 mg/L has been calculated for the effects of the test substance on the mortality of the Green Algae and Aquatic plants. This result signifies that the test substance is not expected to be toxic.
A reliable NOEC value of 178.832 mg/L has been calculated for the effects of the test substance towards Green Algae and Aquatic plants. Therefore the test substance has been predicted to be non toxic.
The available data for saltwater aquatic plants other than algae are limited and to obtaine the value for PNECs for saltwaters is taken account a assesment factor 10 to extrapolate to LC50 following the “Guidance on Information Requirement and Chemical Safety Assessment R.10: Characterisation of dose [concentration]- response for environment”and “Table R.10-5 Assessment factors proposed for deriving PNEC water for saltwater for different data sets”, to account for the possibility that greater taxonomic diversity in the marine environment makes it likely that some marine taxa may be more sensitive than the most sensitive freshwater taxa.

Key value for chemical safety assessment

EC50 for freshwater plants:
1 368.296 mg/L
EC50 for marine water plants:
136.83 mg/L
EC10 or NOEC for freshwater plants:
178.832 mg/L
EC10 or NOEC for marine water plants:
17.88 mg/L

Additional information

A 96 h LC50 value of 1368.296 mg/L has been calculated for the effects of the test substance on the mortality of the Green Algae and Aquatic plants. This result signifies that the test substance is not expected to be toxic .

A reliable 96 h LC50 value of 1368.296 mg/L has been calculated for the effects of the test substance towards Green Algae and Aquatic plants. Therefore the test substance has been predicted to be non toxic.

A NOEC value of 178.832 mg/L has been calculated for the effects of the test substance on the mortality of the Green Algae and Aquatic plants. This result signifies that the test substance is not expected to be toxic.

A reliable NOEC value of 178.832 mg/L has been calculated for the effects of the test substance towards Green Algae and Aquatic plants. Therefore the test substance has been predicted to be non toxic.

The available data for saltwater aquatic plants other than algae are limited and to obtaine the value for PNECs for saltwaters is taken account a assesment factor 10 to extrapolate to LC50 following the “Guidance on Information Requirement and Chemical Safety Assessment R.10: Characterisation of dose [concentration]- response for environment”and “Table R.10-5 Assessment factors proposed for deriving PNEC water for saltwater for different data sets”, to account for the possibility that greater taxonomic diversity in the marine environment makes it likely that some marine taxa may be more sensitive than the most sensitive freshwater taxa