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EC number: 225-805-6
CAS number: 5089-70-3
In the key in vivo skin and eye irritation studies for (3-chloropropyl)triethoxysilane (DCC, 1995c and DCC, 1995d), the substance was not irritant to rabbit skin or eyes.
The key skin and eye
irritation studies were selected as the only available studies for these
endpoint that were carried out in accordance with the relevant OECD test
guideline and GLP (reliability 1). A further study for each endpoint
complying with an EPA guideline and GLP (also reliability 1) found mild
and transient skin and eye irritation. Several non-guideline and/or
non-GLP Reliability 2 studies (four in the case of skin irritation and
three for eye irritation) were also available. All these studies
supported the classification not irritant to the skin and eyes of the
Based on reliable in vivo skin and eye
irritation data, (3 -chloropropyl)triethoxysilane does not meet the
criteria for classification as irritant according to EU Directive
67/548/EEC and Regulation 1272/2008.
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