Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 225-805-6
CAS number: 5089-70-3
No long-term toxicity to fish data are available for the registered
substance, which moderately rapidly hydrolyses to
(3-chloropropyl)silanetriol and ethanol (half-life: 35 hours at 25°C and
pH 7). Chemical safety assessment and PNECs are based on the parent
substance and the silanol hydrolysis product.
Measured short-term aquatic toxicity data are available for the
registered substance, (3-chloropropyl)triethoxysilane, in which, test
organisms were exposed to a mixture of parent substance and hydrolysis
products. These data are currently used to derive PNECs for the parent
Short-term tests conducted with fish and algae (according to OECD 203
and 201, respectively) are ongoing with the registered substance. These
tests are designed to maximise the exposure of the test organisms to the
parent substance. Once the results of these studies have become
available, long-term aquatic testing with the most sensitive trophic
level (either Daphnia or
fish) will be proposed with the parent substance. The tests will be
conducted to fulfil the data requirements for the parent substance.
Long-term toxicity testing with fish is therefore not currently
required, until the results of the short-term studies with fish and
algae are available.
In addition, based on the current short-term aquatic data set for the
parent substance, the most sensitive trophic level is invertebrates,
where some toxicity was observed below 100 mg/l (Daphnia 48-hour
EC50 21.2 mg/l). A PNEC has been derived
for the purpose of chemical safety assessment using the invertebrate
48-hour EC50 value of 21.2 mg/l as the
starting point. An assessment factor of 1000 was applied to derive the
freshwater PNEC. Using this PNEC, Risk Characterisation Ratios (RCRs)
are below 1. For a narcotic chemical without a specific mode of toxic
action, it is unlikely that the aquatic PNEC would be significantly
over-estimated using this method.
Based on the highest freshwater RCR available for the parent substance,
(3-chloropropyl)triethoxysilane (0.627 mg/l) with a corresponding
Predicted Environmental Concentration (PEC) of 0.013 mg/l, the
PNECaquatic (freshwater) value would need to be =0.013 mg/l to result in
RCR values =1. This value is 1.63 times lower than the current
PNECaquatic (freshwater), based on the short-term dataset (0.0212 mg/l).
A PNECaquatic (freshwater) value of =0.013 mg/l would correspond to a
long-term EC10 or NOEC value of =0.65 mg/l
when applying an assessment factor of 50, indicating high toxicity which
was not observed in the existing short-term dataset.
Overall, until the results of the new studies become available, it is
concluded that the risk characterisation conclusion is sufficiently
Details on how the PNECs and the risk characterisation ratios have been
derived can be found in IUCLID Section 6.0, CSR Section 7.0, and
Chapters 9 and 10 of the Chemical Safety Report, respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Dette websted anvender cookies for at sikre dig den bedste brugeroplevelse.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again