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EC number: 225-805-6
CAS number: 5089-70-3
The measured concentration of the test substance after 0,
24, 48, and 72 hours was determined to be 119, 103/110
(indicating stability within 24 hours), 105, and 102 mg/l, respectively,
based on Dissolved Organic Carbon measurements.
The deviation of the analytical results was within 20%,
such that the concentrations were reported as nominal.
0 hr 24 hr 48 hr 72 hr
119 103*/110 105 102
*= 24-hour stability control
No mortalities were reported in
the control and 100 mg/L test medium concentration 24, 48, 72 and 96
hours during the test.
96-hour LC50 >100
mg/l (measured) (EU C.1), read-across from
(3-chloropropyl)trimethoxysilane (CAS 2530-87-2, EC 219-787-9). The LC50
is equivalent to >79 mg/l when expressed in terms of the silanol
hydrolysis product, (3-chloropropyl)silanetriol.
There are no reliable
short-term fish toxicity data available for the registered substance
that represent exposure solely to the hydrolysis products, therefore
good quality data for an appropriate structural analogue,
(3-chloropropyl)trimethoxysilane (CAS 2530-87-2, EC 219-787-9) have been
read across. Both substances hydrolyse to the same silanol hydrolysis
product, (3-chloropropyl)silanetriol. The other hydrolysis products are
ethanol and methanol, respectively.
A 96 hour LC50 value
of >100 mg/l (measured) (highest concentration tested) has been
determined for the effects of the read-across substance
(3-chloropropyl)trimethoxysilane (CAS 2530-87-2) on the mortality of Brachydanio
rerio (new name: Danio rerio) (Evonik Degussa, 1994). In view
of the test media preparation method and exposure regime it is likely
that the test organisms were exposed predominantly to the hydrolysis
products of the tested substance. The nominal test concentrations are
supported by DOC analysis.
The results may be expressed
in terms of concentration of the hydrolysis product,
(3-chloropropyl)silanetriol by applying a molecular weight correction:
(MW of silanol = 156.64 / MW of parent = 198.72) * >100 = >79 mg/l. This
value is read across to (3-chloropropyl)silanetriol without further
Above a concentration of
approximately 1000 mg/l, dimeric / oligomeric, cyclic or cross-linked
condensation products could potentially form over time in the aqueous
test media. There was no report of undissolved material (parent
substance or precipitated products) indicated in the study report for
Refer to the discussion in
the Section 6 endpoint summary (Section 7.0 of CSR) and IUCLID Section
13 for further discussion of the approach to chemical safety assessment
for this registration substance, and justification for read-across used.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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