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EC number: 225-805-6
CAS number: 5089-70-3
In the key acute oral toxicity study (DCC, 1995a) an LD50 >2000 mg/kg was determined for male and female rats in a study that was conducted according to OECD 401 and in compliance with GLP. Clinical signs were limited to soft stools and anogenital staining. No abnormalities were detected at necropsy. In the key acute dermal study (DCC, 1995b) an LD50 >2000 mg/kg was determined for rats. There were no clinical signs of toxicity or necropsy findings. No data are available for the inhalation route.
The key acute oral
toxicity study (DCC, 1995a) was selected from five studies of
reliability 1 or 2. Three other studies (at higher dose levels than
current guidelines require) support the conclusion of the key study that
LD50(oral) for rats is >2000 mg/kg (Degussa 1980; Consultox
Labs 1976; Osi, 1996). In the fifth study, which was limited in respect
of the amount of experimental detail available, an LD50of
1297 mg/kg was reported (Unknown, 1975). However, since four more recent
studies clearly show LD50values in excess of 2000 mg/kg, this
result has not been used for classification.
The key acute dermal
toxicity study was selected from three Reliability 1 guideline studies,
all in compliance with GLP and OECD 402 or similar. All studies gave LD50>2000
mg/kg bw for rats or rabbits.
Based on the available data for the oral and dermal routes, (3
-chloropropyl)triethoxysilane is not classified for acute toxicity
according to EU Directive 67/548/EEC and Regulation 1272/2008. No data
are available for the inhalation route.
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