Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 225-805-6
CAS number: 5089-70-3
In the key study for skin
sensitisation performed according to OECD Test Guideline 406 and in
compliance with GLP, (3-chloropropyl)triethoxysilane (CAS 5089 -70 -3;
EC 225 -805 -6) was not sensitising to the skin of guinea pigs (Dow
Corning Corporation, 1995e).
The key sensitisation study was
selected as the most recent guideline study available from four reliable
tests (DCC, 1995e), and was therefore assigned reliability 1. The key
study, and two reliability 2 supporting studies (TNO-CIVO, 1980 and Laboratorium
Für Pharmakologie und Toxikologie,
1976) were guinea pig maximisation tests. In addition, a reliability 1
study using the Buehler method is available (Hüls AG, 1993).
All four studies gave clear negative results.
(CAS 5089-70-3; EC 225-805-6) has been tested in a Guinea-Pig
Maximisation test conducted according to OECD Test Guideline 406 and in
compliance with GLP. During the induction phase, male guinea pigs were
injected intradermally with 5% (w/v) test material (in cottonseed oil),
then after treatment with sodium lauryl sulfate, treated topically with
75% (w/v) test material via a closed patch application to the shoulder
area. After a latency of 14 days, to allow a potential reaction
of the immune system, the animals were challenged with 75% test
substance on the flank. Negative and positive controls were used and the
guinea pigs were observed for a sensitisation response following the
challenge phase. No animals in the test group or in the negative control
group had a sensitisation response. All positive control animals had a
sensitisation response. The sensitisation rate for the test substance
was 0 %, therefore it is not considered to be a skin sensitiser (Dow
Corning Corporation, 1995e).
In a supporting skin sensitisation study using the Buehler method,
conducted according to OECD Test Guideline 406 and in compliance with
GLP, (3-chloropropyl)triethoxysilane was applied undiluted to 19 guinea
pigs over an area of 0.35/0.4 cm3 and occluded. Negative control animals
were used, but a positive control substance was not included. Challenge
was conducted on study day 28 with undiluted test material (occlusive
epicutaneous). At 24-, 48-, and 72-hours post-application, no skin
irritation was observed in either test animals or control animals. There
were no substance-related effects on body weight in either test or
control animals. Based on the non-adjuvant sensitisation test in guinea
pigs (3-chloropropyl)triethoxysilane was not sensitising (Hüls AG, 1993).
Two other studies (TNO-CIVO, 1980
and Laboratorium Für Pharmakologie und Toxikologie, 1976)
were conducted prior to the adoption of the OECD Test Guideline
and GLP. However, they meet generally accepted scientific principles and
support the conclusions that the registered substance does not produce
sensitisation reactions in the skin of guinea pigs.
Based on reliable in vivo studies,
(3 -chloropropyl)triethoxysilane does not require classification for
skin sensitisation according to Regulation 1272/2008. There are no data
to suggest that the substance should be classified as a respiratory
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Dette websted anvender cookies for at sikre dig den bedste brugeroplevelse.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again