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EC number: 225-805-6
CAS number: 5089-70-3
Short-term ecotoxicity data for three trophic levels are available
for(3-chloropropyl)triethoxysilane. The relevant values are:
Fish:LC50 (96 h): 80 mg/l; NOEC:
Daphnia: EC50 (48 h):
21.2 mg/l; NOEC: 2.15 mg/l (Mitterer, K.-E. 2002)
Daphnia: EC50 (48 h): 140
mg/l; NOEC: 100 mg/l (Hüls 1993)
Algae: EC50 (72 h): >819 mg/l;
NOEC 237 mg/l
In addition, a 21-day NOEC value of ≥100 mg/L
has been determined for the effects of(3-chloropropyl)triethoxysilaneon
mortality and reproduction of Daphnia magna when expressed in
terms of nominal concentrations. The result has been reinterpreted by
the reviewer in terms of the mean measured concentration of the test
substance to give a NOEC of ≥66 mg/L.
The PNEC is based on taking the NOECs derived in the algal test and
long-term test with invertebrates into account and applying an
assessment factor of 50. It is noted that the NOEC derived in the
long-term invertebrate test is higher than the EC50 values derived in
the short-term invertebrate and fish tests. The long-term invertebrate
result has however been used as the basis for setting the PNEC for the
invertebrate tests are assigned reliability 1 but the test design used
in the long-term test is more robust in terms of the numbers organisms
that are exposed in each treatment.
apparent discrepancy in the relationship between the two results can be
explained to a large degree by the shallow nature of the dose-response
relationships in both tests which means that there is scope for overlap
of the EC50 and NOEC values when other sources of variability in the
test results are taken into account.
is no significant difference in the susceptibility of fish and
invertebrates indicated in the short-term tests; therefore, there is no
reason to expect that a long-term fish test would give a lower NOEC than
the long-term invertebrate study.
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