Registration Dossier
Registration Dossier
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EC number: 217-168-8 | CAS number: 1761-71-3
Carcinogenicity
Administrative data
Description of key information
4,4'-Methylenedicyclohexanamine is not mutagenic and is not in widespread dispersive use. A carcinogenicity study is not warranted.
Key value for chemical safety assessment
Justification for classification or non-classification
There is insufficient evidence from existing toxicology data on 4,4'-Methylenedicyclohexanamine to classify this substance as a carcinogen.
Additional information
4,4'-Methylenedicyclohexanamine has been well studied for mutagenicity effects and is evaluated as non-mutagenic. As the majority of known carcinogens are mutagens, this suggests that the substance is not carcinogenic. There is no evidence from repeated dose studies on this substance or on structurally related substances to suggest hyperplasia or pre-neoplastic lesions. This is an industrial chemical which is not in widespread dispersive use. Carcinogenicity studies require large numbers of live animals, use of which is allowed only as a last resort by the REACH legislation (Article 25.1). While specific carcinogenicity studies are lacking, there is insufficient evidence of neoplastic risk to warrant proposal of a study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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