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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Reliable study design, but less detail than expected with current protocols. This study precedes establishment of guideline/Good Laboratory Practices

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1966
Report Date:
1966

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Vapour was generated by passing air through 100 ml of liquid test material. Animals were placed in a chamber breathing vapours. The animals were observed for behaviour and, since there were no deaths, were held for 10 days observation.
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Manufactured by Monsanto. No information on purity.

Test animals

Species:
rat
Sex:
male

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
not specified
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
6 h
Concentrations:
0.4%
No. of animals per sex per dose:
4
Control animals:
no

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LC0
Effect level:
0.4 other: %
Based on:
test mat.
Exp. duration:
6 h
Remarks on result:
other: no quantitative data given on concentration
Mortality:
No deaths occurred at 0.4% vapour
Clinical signs:
other: no data
Body weight:
no data
Gross pathology:
no data

Applicant's summary and conclusion

Interpretation of results:
relatively harmless
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
A limit acute inhalation toxicity test was conducted in a whole body protocol using male rats with 0.4% 4-4’-methylenedicyclohexanamine. None of the rats died during the 6 hour exposure or 10 days afterwards. The LC50 is greater than 0.4%.