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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Description of key information

Geometric mean of three short-term toxicity assay EC50 values in Daphnia magna (6.84mg/L, 7.07 mg/L and 9.24 mg/L); each value was a 48-hour EC50 from a key study conducted in accordance with an approved guideline. 

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
7.64 mg/L

Additional information

The use of the geometric mean value to represent the three closely-clustered EC50 values was appropriate, in accordance with Section R.10.3.1.1 of Chapter R.10, Characterization of dose[concentration]-response for environment, of Guidance on information requirements and chemical safety assessment (ECHA, May 2008).

The 48-hour geometric mean EC50 of 7.64 mg/L for Daphnia magna was the representative value for the short-term toxicity of 4,4'-methylenebis(cyclohexylamine) to fish. This value represented one of the three short-term aquatic toxicity values for each of three trophic levels (fish, aquatic invertebrates and aquatic algae and plants). This geometric mean EC50 was the lowest of the three short-term aquatic toxicity values from each of the three trophic levels and was used as the point of departure for the derivation of the PNECaquatic (freshwater).