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Several case reports have been published suggesting an association between a scleroderma-like syndrome and occupational exposure to PACM (4,4'-methylenedicyclohexanamine) and other organic solvents. 

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PACM has been suggested to be the cause of an occupationally-induced scleroderma syndrome in a Japanese epoxy resin polymerization plant, in the years prior to 1980 (Ohshima et al, 1986; Yamakage et al., 1980). Similar physical symptoms were later reported by Yamakage and Ishikawa (1982) among workers exposed to a variety of organic solvents. Other factors, such as infectious agents, nutritional deficits and genetic predisposition were not considered. More recent studies suggest that other components of epoxy resins, such as isocyantes, are contributors to dermal sensitisation and irritation effects. The epidemiologic data do not clearly support the hypothesis that 4,4'-methylenedicyclohexanamine causes a scleroderma-like syndrome in occupationally-exposed workers.