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Description of key information

Low bioaccumulation potential and low risk of concentration in breast milk.

Key value for chemical safety assessment

Bioaccumulation potential:
low bioaccumulation potential

Additional information

PACM’s low molecular weight and moderate water solubility are favorable for absorption through the GI tract. Its moderate log P value will also favor passive diffusion through the skin, especially if compromised due to caustic damage.  These factors are also favorable for distribution throughout the body. The major routes of metabolism of PACM (and of other primary amines) include oxidation, conjugation, and other enzyme-catalyzed reactions. This results in detoxification and excretion in urine or faeces.  These characteristics indicate that PACM has a low bioaccumulation potential and a low potential to concentrate in breast milk.