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EC number: 931-292-6
CAS number: 308062-28-4
Group mean bodyweights (g ± S.D.) of males - Weeks 0 - 6 – F0
Week of treatment
* Bodyweight change Weeks 0 – 6 significantly different from
Controls, p < 0.05 (Multiple t-test).
*** Bodyweight change Weeks 0 - 6| significantly different
from Controls, p < 0.001 (Multiple test).
Group mean bodyweights (g ± S.D.) of males - Weeks 6- 14 – F0
The study design used was comparable to the OECD 416 two-generation
study. Surfactant A was administered in the diet initially, at levels of
750, 1500 and 3000 ppm, to male and female rats of the P0 generation.
However, following a marked inhibition of bodyweight gain at the two
highest levels, these were reduced respectively to 375 and 188 ppm,
after six and a half weeks of treatment. Treatment of the P0 generation
continued at these levels for the remainder of the maturation period and
throughout mating, gestation and lactation. Using selected animals from
the F1 offspring, treatment continued at dietary levels of 188, 375 and
750 ppm throughout maturation, mating, gestation and lactation of a
second generation. Throughout the study, a fourth group serving as
controls, received untreated diet.
The general condition of animals throughout the study was unaffected by
Surfactant A treatment. After the reduction of treatment level's, the
rate of bodyweight gain increased in animals that had been receiving
1500 and 3000 ppm, but, at all treatment levels, absolute bodyweight of
both sexes remained slightly below that of controls. The rate of
bodyweight gain was slightly reduced in parental males at levels of 375
ppm and 750 ppm (not significant), and in parental females at 750 ppm.
Mating performance, fertility and conception rate presented no effects
that could be related to treatment in either generation.
Gestation and parturition proceeded normally and, except for a slight
(not significant) reduction in the number of F2 offspring born at the
750 ppm level. However, there were no adverse effects
of treatment on litter size at birth, live birth index and birth weight
in either generation.
Viability of offspring was unaffected in the first generation, but there
were slight reductions (not significant) in viability of F2 offspring at
the 138 and 750 ppm levels. At all treatment levels the rate of
bodyweight gains of F1 and F2 offspring was reduced (but only on one
occasion, Day 25 post-partum) during the lactation period.
At terminal necropsy of P0 and P1 adults and F1 and F2 offspring, no
macroscopic abnormalities attributable to treatment with Surfactant A
were observed. There were some slight inter-group differences in organ
weights, but the majority were related to bodyweight deficits, and no
treatment-related histopathological changes were shown.
It was concluded from this investigation that dietary administration of
Surfactant A to male and female rats for two generations, at
concentrations of 188, 375 and 750 ppm, was associated with slight
reductions in weight gain of both parents and offspring, but was without
adverse effect on their mating performance and fertility or on
development of the offspring.
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