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EC number: 931-292-6
CAS number: 308062-28-4
The relationship between the long-term feeding of commercial amine
oxides, the development of cataracts, and the metabolism of the test
substance in rats was studied. A group of rats (groups consisted of 2
male and 2 female rats) was treated with commercial amine oxide for 130
days to induce cataracts in a portion of the group, then a single dose
of the radioactive test substance was administered in the diet to both
the commercial amine oxide-treated rats and control rats. The metabolite
in the urine from these groups of rats were similar both qualitatively
and quantitatively by cation exchange chromatography. In another
experiment, the urinary metabolites excreted by the commercial amine
oxide-treated rats after they had been fed the test substance in diet
for 10 days were similar whether or not they had developed cataracts
during the commercial amine oxide treatment phase.
The tissue distribution of radioactivity in rats fed the test substance
showed no differences that could be attributed to either treatment with
the commercial amine oxide or to cataract development. For all groups,
radioactivity was widely distributed in the body. The tissue
concentrations of radioactivity were generally equal to or less than the
plasma concentration. The only tissues that consistently concentrated
radioactivity were the liver, the adrenal glands, and the kidneys. There
was no concentration of radioactivity in the eye relative to the plasma
and no radioactivity at all was detected in the lens.
It was concluded that commercial amine oxide-treated rats that did or
did not develop cataracts and control rats metabolized the test
substance in the same way. Therefore, even assuming that the test
substance is the cataractogenic agent in the commercial amine oxide
preparation, a metabolically unique subpopulation of rats that might be
predisposed to cataract formation was not detected.
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