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EC number: 931-292-6
CAS number: 308062-28-4
Table 1: Skin reactions observed during the study
Animal No. & sex
Skin reactions on test day
m = male E
= erythema N
f = female Oe
= Oedema 0
= no pathological findings
The acute dermal toxicity of the substance was investigated in a GLP
study performed to OECD 402. The substance was applied as a solution in
water to the skin of 5 male and 5 female rats (CD/Crl: CD(SD)) at a dose
of 2000 mg AO/kg bw and covered with an occlusive dressing for 24 hours.
After completion of the exposure period the dressing was removed. There
were no deaths or signs of systemic toxicity during the 14 -day
observation period and animals showed the expected bodyweight gains.
Erythema (grade 2-4) was observed at the application site in all 5 males
and 5 females immediately after patch removal until test day 6. No
Oedema was noted at any time period. All reactions cleared after 7 days.
Necropsy revealed no macroscopic findings. The LD50 was 2000 mg AO/kg bw.
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