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EC number: 931-292-6
CAS number: 308062-28-4
The 72-h ErC50 for algae of 0.143 mg AO/L is calculated as the geometric mean of the results from four reliable studies performed on Pseudokirchnerella subcapitata which appears to be the most sensitive algal species based on the available data.
The 28-d NOEC of 0.067 mg AO/L is derived from a periphyton microcosm study in which more than 110 taxa of algae were exposed to the substance.
Six reliable acute toxicity studies are available. In the key study
[Ginkel & Kroon (1990)] performed according to OECD TG 201 under GLP
Pseudokirchnerella subcapitata were exposed to the substance under
static conditions for 72 hours at nominal concentrations of 0, 0.020,
0.039, 0.078, 0.155 or 0.31 mg AO/L. The ErC50 (72 h) was 0.266 mg AO/L.
In three supporting studies performed according to OECD TG 201
Pseudokirchnerella subcapitata were exposed to the substance for 72
hours under static conditions. ErC50 values of 0.159 mg AO/L [Brill J
(2010)], 0.12 mg AO/L [Hanstveit & Oldersma (1997)] and 0.082 mg AO/L
[Hanstveit & Oldersma (1997)] were reported. Exposure of Chlorella
vulgaris to the substance for 72 hours under static conditions in
accordance with OECD TG 201 resulted in an ErC50 of 1.14 mg AO/L [Vreys
(2003)], whilst exposure of Desmodesmus subspicatus to the substance for
72 hours under static conditions in accordance with OECD TG 201 resulted
in an ErC50 of 0.25 mg AO/L [Scheerbaum (2000)].
According to the Guidance to Regulation (EC) No 1272/2008 on
classification, labelling and packaging (CLP) of substances and
mixtures, page 408, when larger data sets (four or more values) are
available for the same species, the geometric mean of toxicity values
may be used as the representative toxicity value for that species.
Taking this guidance into account, the geometric mean 72 -h ErC50 for
Pseudokirchnerella subcapitata is 0.143 mg AO/L.
The toxicity of the substance to algae was evaluated in a 28 -day
freshwater periphyton microcosm assay. The microcosm was composed of a
complex consortia of bacterial, cyanobacterial, algal, and fungal
species, and included 110 taxa of algae (notably 87 diatom, 12 green, 7
blue-green, 2 euglenoid, 1 chrysophyte and 1 red). Two substrates
(tiles, cobbles) were naturally colonised for 5 weeks in high quality
flowing streams/rivers in Ohio. The periphyton-colonised tiles & cobbles
were then brought into the laboratory and placed in a 28 day flow
through test of the substance. Periphyton communities were exposed to 0,
6.25, 12.5, 25, 50 or 100 µg
AO/L (nominal) for 28 days. Mean measured concentrations were 4.3
(control), 8.6, 9.2, 16.1, 33.1 or 67.1 µg
AO/L. There were clear location (i.e. colonisation stream) and substrate
effects in this study. Tile and cobble were substantially different, as
were the Little Miami River and Big
Derby Creek communities. Adverse responses were absent by day 28
in all three communities. There were significant increases in some
endpoints at the 2 highest test concentrations (50, 100 µg/L,
nominal), but there were no significant decreases (adverse effects) for
any endpoint. The No-Observed Effect Concentration (NOEC) of the
substance to the periphyton community was determined to be >67 µg
AO/L, the highest test concentration evaluated (mean measured
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