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EC number: 931-292-6
CAS number: 308062-28-4
The skin sensitization potential of C12-C14-Alkyl) dimethylamines,
N-oxides ( OG-Base E2009.01) was assessed in a human repeat insult patch
study. Preliminary irritant study was performed with 0.25% and 0.75%
test material aquoues solution and 0.75% concentration was used in main
study. A total of 78 subjects were exposed to 9 induction patches
containing 0.75% aqueous C12-C14-Alkyl)dimethylamines, N-oxides (
OG-Base E2009.01) under occlusion for a period of 3 weeks. Patches were
removed 24 hours after each application and patch sites were graded at
48 hour after patch application prior to the next patch application.
After a 2 week rest period, subjects were challenged with 0.75% aqueous
C12-C14-Alkyl)dimethylamines, N-oxides ( OG-Base E2009.01) 24 hour patch
exposure. Challenge patch sites were graded at 48 and 96 hours after
83 subjects participated in this study, 78 /83 subjects completed the
study. A total of 5 subjects dropped out because of reasons unrelated to
the test. 31/78 subjects were observed with mild erythema grade1 during
the challenge exposure. No positive responses indicative of delayed
contact hypersensitivity was observed. The test material OG-Base
E2009.01 (30% C12 -14 Dimethyl amine oxide) did not produce skin
sensitization in humans.
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