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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Link to relevant study record(s)

Description of key information

A 48-hr acute toxicity study with Daphnia magna exposed to di-n-butyl ether (DnBE) was conducted following U.S.EPA guidelines (1975). This non-GLP study reported a 48-hr EC50 value of 26 mg/L from a static acute test.

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
26 mg/L

Additional information

Three short-term invertebrate toxicity tests were available for dibutyl ether (DnBE) with the freshwater cladoceran, Daphnia magna. The key study was from the published literature followed US-EPA guidelines (1975) and was rated a Klimisch score of 2, having been conducted prior to the requirement for GLP certification. The 48-hr EC50 value reported from this study was 26 mg/L. Two additional supporting studies also utilized the cladoceran, Daphnia magna, and were conducted for 24-hr following methodology similar to OECD 202. These two studies reported 24-hr EC50 values of >150 amd 110 mg/L.