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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to microorganisms

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Administrative data

Link to relevant study record(s)

Description of key information

A toxicity test in microorganism was conducted on acitivated slude of a predominately domestic sewage exposed to dibutyl ether (DnBE) following OECD guideline 209.  The 30 min EC50 was > 1000 mg/L, while the reported NOEC was >=1000 mg DnBE/L.

Key value for chemical safety assessment

EC50 for microorganisms:
1 000 mg/L
EC10 or NOEC for microorganisms:
1 000 mg/L

Additional information

Two toxicity test with microorganisms are available for dibutyl ether (DnBE). The keys study was rated a Klimisch score of 1, followed GLP and OECD 209. This study exposed acitivated sludge from a domestic sewage plant to DnBE. The resulting 30 min EC50 value was > 1000 mg/L and the 30 min NOEC was >=1000 mg/L. A supporting study was also available that was rated a Klimisch score of 2. This study followed methodology developed by the authors and exposed Pseudomonas putdia for 16-hr to DnBE. The reported 16-hr NOEC was > 50 mg/L, the highest concentration tested.