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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1954
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Well performed study, study performance before implementation of GLP, purity of test item not reported.
Cross-referenceopen allclose all
Reason / purpose:
reference to same study
Reason / purpose:
reference to other study

Data source

Reference
Reference Type:
publication
Title:
Range-finding toxicity data, List V
Author:
Smyth, H.F., Carpenter, C.P., Weil, C.S., Pozzani, U.C.
Year:
1954
Bibliographic source:
Arch. Ind. Hyg|Occup. Med., 10, 61-68

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
not applicable
GLP compliance:
no
Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
dibutyl ether (purity not indicated)

Test animals

Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals and environmental conditions:
TEST ANIMALS
- Source: raised at Mellon Institute of Industrial Research
- Age at study initiation: young adults
- Weight at study initiation: 90-120 grams

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on oral exposure:
Single exposure
Doses:
other
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- The tested chemicals were diluted with water, corn oil, or a 1 % solution of sodium 3,9-diethyl-6-tridecanol sulfate (Tergitol Penetrant 7) when
necessary to bring the volume given to one rat to between 1 and 10 ml. However, it is unknown which (if any) solvent and at which concentration was used in the case of dibutyl ether.
Statistics:
The most probable LD50 value and its fiducial range were estimated by the method of Thompson (1947) using the tables of Weil (1952).

Results and discussion

Preliminary study:
not applicable
Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
7 400 mg/kg bw
Based on:
test mat.
95% CL:
> 6 410 - < 8 530
Mortality:
no information available
Clinical signs:
no information available
Body weight:
no information available
Gross pathology:
no information available
Other findings:
no information available

Any other information on results incl. tables

None

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Under the conditions of the study, the acute oral LD50 of dibutyl ether is 7400 mg/kg body weight with 95% CL ranging between 6410 - 8530 mg/kg body weight and will not be classified.
Executive summary:

In this study, single dose oral toxicity for rats was estimated by intubation of dosages in a logarithmic series to groups of five male Carworth-Wistar rats (90 to 120 g), raised at the Mellon Institute of Industrial Research, University of Pittsburgh, USA. The tested chemicals were diluted with water, corn oil, or a 1 % solution of sodium 3,9-diethyl-6-tridecanol sulfate (Tergitol Penetrant 7) when necessary to bring the volume given to one rat to between 1 and 10 ml. However, it is unknown which (if any) solvent and at which concentration was used in the case of dibutyl ether. Fourteen days after dosing, mortality was considered complete. The most probable LD50 value and its fiducial range were estimated by the method of Thompson (1947) using the tables of Weil (1952). Clinical signs were not reported. Under the conditions of the study, the acute oral LD50 of dibutyl ether is 7400 mg/kg body weight with 95% CL ranging between 6410 - 8530 mg/kg body weight and will not be classified.