Registration Dossier

Administrative data

Endpoint:
bioaccumulation in aquatic species: fish
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No information given whether the study was performed according to GLP.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1992

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 305 C (Bioaccumulation: Test for the Degree of Bioconcentration in Fish)
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:

dibutyl ether (purity not indicated)
Radiolabelling:
not specified

Test solutions

Vehicle:
not specified

Test organisms

Test organisms (species):
Cyprinus carpio

Study design

Route of exposure:
aqueous
Test type:
flow-through
Water / sediment media type:
natural water: freshwater
Total exposure / uptake duration:
42 d

Test conditions

Test temperature:
25 °C
Nominal and measured concentrations:
0.2 and 0.02 mg/l

Results and discussion

Bioaccumulation factor
Type:
BCF
Value:
47 - 83 dimensionless
Basis:
whole body w.w.
Time of plateau:
6 wk
Remarks on result:
other: Conc.in environment / dose:0.2 mg/l
Depuration
Elimination:
not specified

Any other information on results incl. tables

The average lipid content of the fishes was 4.6 %.

At the tested concentration of 0.2 mg dibutyl ether/l a BCF
of 47-83 was measured. At the further tested concentration
of 0.02 mg dibutyl ether/l a BCF of 30 to 114 was measured.

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
The average lipid content of the fishes was 4.6 %. At the tested concentration of 0.2 mg dibutyl ether/l a BCF of 47-83 was measured. At the further tested concentration of 0.02 mg dibutyl ether/l a BCF of 30 to 114 was measured.