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Ecotoxicological information

Short-term toxicity to fish

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Description of key information

A 96-hour flow-through toxicity study was available for Dibutyl ether (DnBE) exposed to fathead minnows (Pimephales promelas).  The 96-hr LC50 value was reported as 32.3 mg/L (95% C.L. 30.1-34.7 mg/L).

Key value for chemical safety assessment

LC50 for freshwater fish:
32.3 mg/L
LC50 for marine water fish:
450 mg/L

Additional information

A total of five freshwater and one saltwater acute toxicity tests with fishes exposed to dibutyl ether (DnBE) are available, all following available guidelines and receiving Klimisch scores of 2, having been conducted prior to the requirement for GLP certification. The key study, was conducted in a flow-through system with the fathead minnow (Pimephales promelas) for 96 hours and reported an LC50 value of 32.3 mg/L (95% C.L. 30.1-34.7 mg/L). This study is supported by five additional studies that include a second 96-hr flow-through exposure with Pimephales promelas (LC50 = 32.5 mg/L) and a 48-hr semi static test with Oryzias latipes that determined an LC50 value of 30.7 mg/L . Two supporting studies with Leuciscus idus melantous reported 48-hr LC50 values of 71 and 193 mg/L. A saltwater acute test with Cyprinodon variegatus resulted in a 96-hr LC50 value of >450 mg/L.