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EC number: 216-600-2
CAS number: 1623-05-8
The mutagenic activity of the test article was evaluated in the
Bacterial Reverse Mutation Assay with S. typhimurium (strains: TA1535,
TA97, TA98, and TA100) and E. coli (strain: WP2uvrA) in the presence or
absence of a metabolic activation system (S9-mix: Aroclor 1254-induced
rat liver). This study was performed in accordance with EPA GLP 40CFR792
and OECD GLP C(81)30(Final), Annex 2. The study design was based on OECD
471 (1997). The maximum concentration was limited to one half of the
lower exposure limit (1%) because of the volatility of the test
substance. The test article was exposed to the cells at 0.1, 0.2, 0.3,
0.4, and 0.5% in the presence or absence of S9-mix. Dry compressed air
was used for the negative control. Strain specific positive controls
were tested in parallel. Two independent trials were performed for each
concentration. Positive and negative controls performed as expected
indicating that all criteria for a valid study were met. No substantial
increases in revertant colonies were observed in test article-treated
cultures in the presence or absence of S9-mix. Based on the
results of the study, the test article was negative in the Bacterial
Reverse Mutation assay in the presence and absence of metabolic
activation (S9 mix).
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