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EC number: 216-600-2
CAS number: 1623-05-8
The acute oral toxicity potential of the test article (liquid,
batch 10B1001) was evaluated in male and female rats. This study was
performed in accordance with OECD GLP (1999). The study design was based
on OECD 401 (1987) and Directive 92/69/EEC, guideline B.1 (1992). The
test article was emulsified at 20% in deionized water. Rats (5/sex)
received 2000 mg/kg test article via a single oral gavage. Parameters
evaluated: clinical observations (daily), body weights (weekly), and
gross necropsy (termination). All animals were terminated 14 days
post-dose. All animals survived. Squatting posture (9 of 10 animals,
9/10), drawn in flanks (2/10), irregular respiration (10/10), and
swollen abdomen (6/10) were noted in animals from 1 hour to 8 hours
post-dose. Drawn in flanks and irregular respiration were not present at
24 hours after dosing. Swollen abdomen persisted in males (1 to 4 of 5
animals) through Day 11 and in females (2/5) through Day 4. Squatting
posture persisted in males (2/5) through Day 4 and was not present in
females at 24 hours after dosing. All animals were normal on Day 12.
There were no abnormalities in body weights or gross necropsy
observations. Based on the results of this study, the oral LD50 of the
test article is greater than 2000 mg/kg body weight.
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