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EC number: 216-600-2
CAS number: 1623-05-8
The acute dermal toxicity of the test article (clear, colorless liquid,
batch 114B1005) was evaluated in male and female Sprague-Dawley rats.
This study was performed in compliance with OECD GLP regulations. The
test method was based on OECD 402 (1987). Rats (5/sex) were clipped of
hair to create a dorsal trunk test site that was not less than 10% of
the total body surface area. Animals were dosed with 2000 mg/kg (1.29
mL/kg) of the test article. The test substance was held in contact with
the skin with a dressing, consisting of a surgical gauze patch,
successively covered with aluminum foil and Coban elastic bandage. A
piece of Micropore tape was additionally used for fixation of the
bandages in females only. At 24 hours, the wrappings were removed and
the test sites were washed with tap water. Clinical observations were
recorded periodically on the day of dosing and then once daily for 14
days. Body weights were recorded pretest, day 8 and day 15. All animals
were examined for gross pathology after termination on Day 15. All
animals survived. Restless behavior, piloerection and/or
chromodacryorrea were noted for the animals on day 1. The changes noted
in body weight gain in males and females were within the range expected
for rats used in this type of study and were therefore considered not
indicative of toxicity. No abnormalities were found at macroscopic post
mortem examination of the animals. Based on the results of this study,
the dermal LD50 of the test article is greater than 2000 mg/kg.
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