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EC number: 216-600-2 | CAS number: 1623-05-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption, other
- Remarks:
- calculation
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- key study
- Study period:
- 01 October 2014 - 13 November 2014
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: calculation according to accepted formulas
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Deviations:
- no
- Principles of method if other than guideline:
- Calculation performed using the equation provided in the European Chemicals Bureau: Technical Guidance Document on Risk Assessment, Chapter 4 "Predominantly hydrophobobics".
- GLP compliance:
- no
Test material
- Reference substance name:
- Company code
- IUPAC Name:
- Company code
- Details on test material:
- - Name of test material (as cited in study report): MTDID 16437
- Substance type: single component
- Physical state: Clear colourless liquid
- Storage condition of test material: At room temperature in the dark under nitrogen
Constituent 1
- Radiolabelling:
- no
Study design
- Test temperature:
- Not Applicable
HPLC method
- Details on study design: HPLC method:
- EQUIPMENT
- Apparatus: Acquity UPLC system (Waters, Milford, MA, USA)
- Type: UPLC
- Type, material and dimension of analytical (guard) column: Acquity UPLC HSS Cyano, 100 mm × 2.1 mm i.d., dp = 1.8 μm (Waters),
- Detection system: Acquity UPLC PDA detector (Waters),
- Column temperature: 23°C ± 1°C
- Flow: 0.4 ml/min
- Injection volume: 5 μl
- UV detection: 210 nm
MOBILE PHASES
- Type: 55/45 (v/v) methanol/0.01 M phosphate buffer at pH 7
- Experiments with additives carried out on separate columns: no
- pH: 7
- Solutes for dissolving test and reference substances: methanol and 55/45 (v/v) methanol/0.01M phosphate buffer pH 7
DETERMINATION OF DEAD TIME
- Method: by means of homologous series / by inert substances which are not retained by the column: unknown
REFERENCE SUBSTANCES
- Identity: 4,4’-DDT (CAS# 50-29-3) (98.2%, Supelco, Bellefonte, PA, USA).
DETERMINATION OF RETENTION TIMES
- Quantity of test substance introduced in the column: 0.51 - 3.875 µg (5 µl of nominal concentrations of 102 - 775 mg/l).
- Quantity of reference substances: not reported
- Intervals of calibration: not reported
REPETITIONS
- Number of determinations: not reported
EVALUATION
- Calculation of capacity factors k': not reported
- Calculation of retention times: None
- Determination of the log Koc value: None
Results and discussion
Adsorption coefficient
- Type:
- log Koc
- Value:
- 3.34 dimensionless
- Remarks on result:
- other: Calculated using log Kow = 4.0
Results: HPLC method
- Details on results (HPLC method):
- - Retention times of reference substances used for calibration: 5.8 minutes
- Details of fitted regression line (log k' vs. log Koc): not reported
- Graph of regression line attached: none
- Average retention data for test substance: no peak from test substance
Any other information on results incl. tables
The soil and sediment partition coefficient (log Koc) of PPVE was calculated using the equation from European Chemicals Bureau: Technical Guidance Document on Risk Assessment, Chapter 4, 'Predominantly hydrophobics". The log Koc is given as: Log koc = 0.81 log Pow + 0.10.
From the experimentally determined log Kow value of 4.0, the log Koc (soil and sediment partition coefficient) of PPVE is calculated to be 3.34.
Applicant's summary and conclusion
- Conclusions:
- The soil and sediment partition coefficient (log Koc) of PPVE was calculated to be 3.34 using the equation from European Chemicals Bureau: Technical Guidance Document on Risk Assessment, Chapter 4, 'Predominantly hydrophobics".
- Executive summary:
The adsorption coefficient (Koc) of the test substance was attempted using OECD 121: "Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC)” method.
The test substance was dissolved in methanol and 55/45 (v/v) methanol/0.01M phosphate buffer pH 7 at nominal concentrations of 102 - 775 mg/l. The adsorption coefficient (Koc) of the test substance was determined using high performance liquid chromatography with UV detection (HPLC-UV). None of the test substance solutions showed a response using the HPLC-UV method (data not shown). The method was checked by analysis of a reference solution of 4,4’-DDT (CAS# 50-29-3), which had a retention time of 5.8 minutes.
Based on the results, it was concluded that it was not possible to determine the Koc of the test substance using the HPLC method. Alternatively, the Koc and log Koc values were calculated using a quantitative structure activity relationship (QSAR).
The soil and sediment partition coefficient (log Koc) of PPVE was calculated using the equation from European Chemicals Bureau: Technical Guidance Document on Risk Assessment, Chapter 4, 'Predominantly hydrophobics". The log Koc is given as: Log koc = 0.81 log Pow + 0.10. From the experimentally determined log Kow value of 4.0, the log Koc (soil and sediment partition coefficient) of PPVE is calculated to be 3.34.
This data was calculated according to accepted Technical Quidance document, it is accepable with restriction and a key study.
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