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EC number: 216-600-2
CAS number: 1623-05-8
The 4-hour acute
inhalation lethality of the test article was determined in
Sprague-Dawley rats. The study was conducted in compliance with GLP
(1982) regulations. The test method was based on OECD Guideline 403.
Rats (5/sex/group) were exposed to 0 (negative control), 12.4, 21.8,
40.8, or 58.7 mg/L test article for a single, whole body 4-hour
exposure. Rats were observed continuously during exposure and at least
twice daily throughout the study. Clinical signs were recorded at the
end of the chamber equilibration period, at 0.25, 0.5, and 1.0 hours and
then at hourly intervals during the exposure. During the recovery period
clinical signs were recorded once in the morning and then as necessary
following a later check for clinical signs of toxicity. All rats were
weighed daily until the end of the recovery period (Day 14). A gross
necropsy was performed on all surviving rats on Day 14 following
Following review by the
sponsor of the procedures for cleaning of the sample cylinders for the 2
consignments of the test compound, the sponsor considers that the first
consignment, which was used for the 12.4, 21.8 and 40.8 mg/L exposures,
may have been contaminated with hydrofluoric acid formed following
incomplete drying of the cylinder used. The second consignment was used
for the exposure at 58.7 mg/L test article.
No mortality was
observed in animals exposed to 58.7 mg/L; clinical signs of toxicity
observed during the exposure included fast respiration and piloerection
which had resolved by one day post-exposure. Food consumption was normal
and water consumption was slightly above that of the control animals
during the recovery period. At necropsy, no abnormalities were observed
in rats exposed to 58.7 mg/L except for one female that demonstrated
pale raised areas in the lungs.
During the 40.8 mg/L
exposure, partially closed eyes, fast respiration and restless behavior
were observed which lasted for up to 4 days post-exposure. Three males
and 1 female (total mortality 4/10) died within 2 days of the
exposure. Food and water consumption was reduced for up to 3 days
following the 40.8 mg/L exposure and animals demonstrated body weight
losses for 2 days post-exposure. At necropsy, slight to severe
congestion and dark subpleural foci in the lungs, wet fur, red or clear
discharge from the nose and white frothy fluid were observed. No adverse
clinical signs of toxicity were noted during the 21.8 mg/L exposure;
however, exaggerated and fast respiration, immobility convulsions in
response to sound were noted for up to 3 days post-exposure. Two male
and 3 females were found dead (5/10 total mortality) between days 1 and
2 post-exposure. Food and water consumption was reduced for up to 3 days
following the 21.8 mg/L exposure and animals demonstrated body weight
losses for 2 days post-exposure. At necropsy, slight to sever congestion
and dark subpleural foci in the lungs, wet fur, red or clear discharge
from the nose and white frothy fluid were observed. Restless behavior
and fast respiration were noted during the 12.4 mg/L exposure and
exaggerated respiration was noted for up to 3 days post-exposure. One
female was found dead (1/10 total mortality) one day post-exposure. Food
and water consumption was reduced for up to 3 days following the 12.4
mg/L exposure and animals demonstrated body weight losses for 2 days
post-exposure. At necropsy, slight to severe congestion and dark
subpleural foci in the lungs, wet fur, red or clear discharge from the
nose and white frothy fluid were observed.
Therefore, based on the
results of this study, the 4-hour acute inhalation LC50 of
the test article is greater than 58.7 mg/L, vapor.
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