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EC number: 216-600-2
CAS number: 1623-05-8
The primary dermal irritation potential of the test article was
determined in New Zealand White rabbits. The study was conducted in
compliance with OECD GLP (1997) regulations. The test method was based
on OECD 404 (1992). The test article (0.5 mL) was administered unchanged
to clipped skin on a 2.5 x 2.5 cm cellulose patch on a piece of surgical
plaster on the dorsal region of each rabbit. The plaster was fixed to
the prepared skin area and then covered with a semi-occlusive bandage.
The test article was left on the skin for a 4 hour exposure. After the
exposure period, all remnants of the test article were carefully removed
from the skin by washing with warm tap water. Examinations of the skin
took place after 30 -60 minutes as well as 24, 48, and 72 hours after
patch removal. Erythema, eschar formation and edema were evaluated and
scored according to the Draize scale. No signs of irritation were
observed during the study. All erythema and edema scores were 0 at 24,
48 and 72 hours in all animals. Based on the results of the study, the
test article is not irritating to skin.
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