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EC number: 216-600-2 | CAS number: 1623-05-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0 mg/L
- Assessment factor:
- 1 000
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 0.005 mg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0 mg/L
- Assessment factor:
- 10 000
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 100 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 0.102 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 0.01 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- PNEC air
- PNEC value:
- 0.2 µg/m³
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 0.012 mg/kg soil dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
PNEC derivations for persistent degradation products:
Hydrogen Fluoride (CAS# 7664-39-3): Using available aquatic toxicity data(1) PNECs were calculated to be 0.4 mg/L for freshwater and 0.04 mg/L for marine water. Acute and chronic results were available for three taxonomic groups. For the calculation of the Freshwater PNEC a 21-day LC05 (equivalent to NOEC) of 4.0 mg/L was obtained from a study with Oncorhynchus mykiss. Therefore, an AF of 10 was applied to the fish NOEC, which is the lowest of the three long-term NOECs. Although there are acute data available for marine species, there are no chronic data and there is acute data available for only one additional taxa (mollusk). Therefore, the PNEC derived from the most sensitive chronic study conducted in freshwater is divided by 10 to derive the marine PNEC. For the STP PNEC, a NOEC of 510 mg/L was available for activated sludge respiration inhibition. An assessment factor of 10 was applied to the NOEC to derive a PNEC of 51 mg/L for STP. No test results for FW Sediment were available. PNEC was extrapolated using the equilibrium partitioning method (EPM) with the freshwater PNEC. PNECsed = (0.783 + (0.0217 x Koc)) x PNECfreshwater, where the Koc was 0.063 and the freshwater PNEC was 0.4 mg/L. PNEC converted to dry weight: (PNEC mg/kg ww) x 4.6 = PNEC of 1.44 mg/kg dry wt. No test results for Marine Sediment were available. PNEC was extrapolated using the equilibrium partitioning method (EPM) with the marine PNEC. PNECmarinesed = (0.783 + (0.0217 x Koc)) x PNECmarinewater, where the Koc was 0.063 and the marine PNEC was 0.04 mg/L. PNEC converted to dry weight: (PNEC mg/kg ww) x 4.6 = PNEC of 0.144 mg/kg dry wt. A large data set of fumigation studies with vegetation was evaluated. Data from studies with a 7-month exposure period were used to derive the PNECair. The lowest value calculated as protective of vegetation was 0.2 ug/m3. Because of the large data set and the long exposure period, no application factor was applied to this protective value to derive the PNEC of 0.2 ug/m3. A great number of soil studies were available. Data from the most sensitive endpoints from long-term studies from three trophic levels were evaluated. An application factor of 10 was applied to the most sensitive NOEC of 106 mg/kg for soil microbe NO3 mineralization. PNEC converted to dry weight: (PNEC mg/kg ww) x 1.13 = PNEC of 12 mg/kg dry weight. HF is an inorganic acid and thus not considered PBT by the REACh criteria. Because this substance is an inorganic acid, and because the Kow value indicates low bioconcentration potential, secondary poisoning is not relevant. Log Kow = -1.4. (1) European Chemicals Bureau European Union Risk Assessment: Hydrogen Fluoride, 2001.
Perfluoropropionic acid (CAS 422-64-0): Using available aquatic toxicity data, the PNECs were calculated to be: 0.0085 mg/L for Freshwater, 0.00085 mg/L for Marine Water, and 1000 mg/L for STP. For the Freshwater PNEC, three short-term tests were available for each of three trophic levels. Pseudokirchneriella subcapitata was the most sensitive of all species. A conservative assessment factor of 1000 was applied to the geometric mean of the two available results. No Marine Water test data was available. The Marine Water PNEC was generated using the most sensitive freshwater results. An Assessment Factor of 10,000 was applied to the geometric mean of the two available results. For the STP PNEC, a NOEC was available for activated sludge. An Assessment Factor of 10 was applied to the NOEC to derive a PNEC for STP. No test results were available for Sediment, Soil (Grassland and Agricultural Soil), or Marine Sediment. These PNECs were extrapolated using the equilibrium partitioning method (EPM) with the Koc = 1.1 L/kg and the freshwater PNEC = 0.0085 mg/L for freshwater sediment and marine PNEC = 0.00085 mg/L for marine sediment. The PNECs for Sediment, Marine Sediment, Grassland and Agricultural Soil were calculated to be 0.0313 mg/kg dw, 0.00313 mg/kg dw, and 0.0018 mg/kg dw respectively. Although PFPA is not readily biodegradable, the bioconcentration factor was found to be ≤4.8 in a laboratory study with fish. This substance is not considered bioaccumulative. Therefore, the PNEC oral is not applicable and was not derived.
Conclusion on classification
PPVE:
CLP Acute Toxicity: Not classified – conclusive although insufficient for classification
CLP Chronic Toxicity: Not classified - conclusive although insufficient for classification
Classification based on LC50 >10 mg/L nominal in fish and rapid hydrolysis to form PFPA (Algal NOEC of 3.47 and 3.71 mg/L)
OZONE DEPLETION: PPVE is not listed in the Montreal Protocol on Substances that Deplete the Ozone Layer. It does not contain reactive halogens (chlorine or bromine) that could play a role in ozone depletion. PPVE is not hazardous to the ozone layer. Conclusive although not sufficient for classification.
Hydrogen fluoride degradation product (CAS# 7664 -39 -3):
CLP Acute Toxicity: Not classified - conclusive although not sufficient for classification.
CLP Chronic Toxicity: Not classified - conclusive although not sufficient for classification.
Classification as per REACH registration. EU risk assessment does not assign environmental classifications.
OZONE DEPLETION: HF is not listed in the Montreal Protocol on Substances that Deplete the Ozone Layer. It does not contain reactive halogens (chlorine or bromine) that could play a role in ozone depletion. HF is not hazardous to the ozone layer. Conclusive although not sufficient for classification.
Perfluoropropionic acid degradation product (CAS 422-64-0):
CLP Acute Toxicity: Not classified - conclusive although not sufficient for classification.
CLP Chronic Toxicity: Not classified - conclusive although not sufficient for classification
Based on the most sensitive species for PFPA being algae with EC50 of 8.5 mg/L (mean of > 6.78 mg/L and 10.6 mg/L), and NOEC of 3.47 mg/L and 3.71 mg/L. PFPA effect concentrations for fish and invertebrates are too high to lead to an acute or chronic classification.
OZONE DEPLETION: PFPA is not listed in the Montreal Protocol on Substances that Deplete the Ozone Layer. It does not contain reactive halogens (chlorine or bromine) that could play a role in ozone depletion. PFPA is not hazardous to the ozone layer. Conclusive although not sufficient for classification.
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