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Toxicological information

Repeated dose toxicity: oral

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Administrative data

Endpoint:
short-term repeated dose toxicity: oral
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Abstract only.

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Eastman Kodak Company; unpublished data, Health, Safety and Human Factors Laboratory, Rochester, N.Y. (1980)
Year:
1980
Bibliographic source:
in: Patty's Industrial Hygiene and Toxicology, 3rd rev.ed., Clayton, G. D., Clayton, F. E. (eds.), John Wiley a. Sons, Inc., New York, 2 C, 4953-4958 (1982).
Reference Type:
review article or handbook
Title:
No information
Author:
Guest D, Katz G, Astil BD
Year:
1981
Bibliographic source:
cited in Patty's Industrial Hygiene and Toxicology. Clayton GD, Clayton FE Vol. 2C, 3 rd. ed.: 4956 - 4958, John Wiley & Sons Inc., USA, ISBN: 0-471-09258-4

Materials and methods

Principles of method if other than guideline:
other: no data
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no data

Test animals

Species:
rat

Administration / exposure

Route of administration:
oral: gavage
Duration of treatment / exposure:
subacute
Frequency of treatment:
10 administrations
Doses / concentrations
Remarks:
Doses / Concentrations:
5, 10 mg/kg/day
Basis:

Results and discussion

Results of examinations

Body weight and weight changes:
no effects observed
Haematological findings:
no effects observed
Clinical biochemistry findings:
no effects observed
Gross pathological findings:
no effects observed
Histopathological findings: non-neoplastic:
effects observed, treatment-related
Details on results:
Slight to moderate alveolar hemorrhage, lipid granuloma in the lungs, moderate to severe granularity of liver cytoplasm. No adverse effect on feed intake, body weight gain, hematology, serum clinical chemistries or gross pathology.

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion