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EC number: 201-204-4
CAS number: 79-41-4
An earlier two years toxicity study was performed to study the tolerance of animals to chronic ingestion of methyl methacrylate (Borzelleca et al. 1964).
Twenty-five male and female Wistar rats were administered three doses of methyl methacrylate in the drinking water for two years. Initial doses of 6, 60 or 2000 ppm were partially raised to 7, 70 and 2000 ppm after 5 months.
A special design was employed to reduce the volatilization and measurements which showed that the methyl methacrylate concentrations remained within 15% of the nominal concentration for 72 hours. Body weight depression was also observed at 2000 ppm but it did not persist beyond the first few weeks of the study. Significant depression of fluid consumption was observed at 2000 ppm, although this tended to regress at the end of the study. Individual observations of depressed food consumption tended to parallel periods of depressed growth. There were significantly increased kidney ratios for female rats at 2000 ppm. These effects were believed to be a consequence of reduced food intake and reduced body weights, and in the absence of any histopathology, were considered as not biologically relevant. Therefore the NOAEL is considered to be >= 2000 ppm, corresponding to 90.3 mg/kg bw/day and 193.8 mg/kg bw/day, for males and females, respectively, on the basis of treatment specific fluid consumption rates and body weights.
No relevant effects were observed after exposure of rats in drinking water up to the highest dose tested (2000 ppm, limited by palatability).
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