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EC number: 201-204-4
CAS number: 79-41-4
Acute oral toxicity
Undiluted methacrylic acid had an LD50 of 1320 mg/kg (Paulet, 1977).
Based on the corrosive properties of the substance this effect can be
attributed to corrosivity rather than systemic toxicity. In two other
tests, where the test material had been administered as a 25 % dilution
in water (Dow, 1957) or a 10 % dilution in corn oil (Easman, 1979), the
LD50 was above 2000 mg/kg in both cases.
Acute inhalation toxicity
Using a valid experimental method, the 4 hour LC50 of MAA to male and
female rats was 7.1 mg/L (1983 ppm; exposure was to a mix of vapour and
Mortality is clearly associated with exposure to aerosol. Exposure to
(saturated) vapour was +/- the same at all concentration levels (3.4-3.7
mg/L). Exposure to vapour alone was not associated with mortality, while
exposure to aerosol increased ( 0.9-4.7 mg/L) in parallel to an increase
Acute dermal toxicity
In a valid screening study, the acute dermal LD50 in rabbits of MAA was
500-1000 mg/kg bw.
MAA is corrosive and fulfils the criteria for acute toxicity category 4
Exposure to MAA vapour alone is not lethal (no classification). Exposure
to MAA aerosols fulfils the criteria for acute toxicity category 4
The dermal toxicity (LD50 500 -1000 mg/kg) is in the range for category
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