Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-204-4
CAS number: 79-41-4
Non-compartmental analysis of the blood concentration data for MAA at
the two doses, gives volumes of distribution of 23 ml (10 mg kg-1) and
35 ml (20 mg kg-1). The clearance of MAA was calculated to be 0.324 L
hr-1 SRW-1 at the 10 mg kg-1 dose and 0.25 L hr-1 SRW-1 at the 20 mg
kg-1 dose. The change in clearance from the lower dose to the higher
dose indicates non-linear saturable metabolism in the rat.
Based on that information, the following kinetic parameters were
determined from a simultaneous fit of the in vivo data to a
one-compartment model with non-linear elimination (Vss = 0.039 L/SRW;
Vmax = 19.8 mg/hrxSRW; Km = 20.3 mg/L; SRW: standard rat weight = 250 g)
the half-life of MAA in blood was calculated to 1.7 min.
The PBPK model data were validated by i.v. administration of MAA in rats
and subsequent analysis of blood from the tail vein.
In conclusion, from a simultaneous fit of the in vivo data to a
one-compartment model with non-linear elimination, the half-life of MAA
in blood was calculated to 1.7 min.
NOTE: Any of data in this dataset are disseminated by the European
Union on a right-to-know basis and this is not a publication in the same
sense as a book or an article in a journal. The right of ownership in
any part of this information is reserved by the data owner(s). The use
of this information for any other, e.g. commercial purpose is strictly
reserved to the data owners and those persons or legal entities having
paid the respective access fee for the intended purpose.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again