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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: As the substance was administered undiluted, it can be expected that the corrosive effects were manifested in the GI tract and the LD50 cannot be attributed solely to systemic toxicity. Very limited documentation of experimental details.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
other: strain: Wistar; 10 animals per group, 900-1750 mg/kg undiluted.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Methacrylic acid (CAS: 79-41-4)
Purity: 99 % administered undiluted
Supplier: Merck

Test animals

Species:
rat
Strain:
Wistar
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
0.9, 1.00, 1.25, 1.50, 1.75 g/kg
No. of animals per sex per dose:
10 males per group at 0.9, 1.00, 1.25 g/kg; 8 males per group at 1.50, 1.75 g/kg
Details on study design:
Animals were observed for 10 days following adminstration of the substance.

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
1 320 mg/kg bw
Mortality:
Dose g/kg Mortality
0.9 0/10
1.00 2/10
1.25 4/10
1.50 6/8
1.75 8/8

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category IV
Remarks:
Migrated information according to GHS-REGULATION (EC) No 1272/2008 Criteria used for interpretation of results: EU
Conclusions:
Using a valid scientific method, the oral LD50 of MAA to male rats was 1320 mg/kg bw.
Executive summary:

Using a valid scientific method, the oral LD50 of MAA to male rats was 1320 mg/kg bw.