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EC number: 201-204-4
CAS number: 79-41-4
Test article group: no dermal irritation to eschar was observed during
the induction phase of the study. After the challenge application no
redness was observed other than slight patchy redness exhibited at 48
hrs by 2/20 animals. The incidence of sensitization was 0/20 and the
severity was 0.0, 0.5 and 0.0 for 24, 48 and 72 hours, respectively.
Vehicle control group:
No dermal irritation to eschar was observed during the induction phase
of the study. After the challenge application no redness was observed
other than slight patchy redness exhibited at 48 hrs by 2/10 animals,
and 3/10 animals at 72 hours. The vehicle site did not exhibit any
Positive control group (1-chloro-2,4-dinitrobenzene): After the
challenge application, moderate redness was observed in 5/5 animals at
24 hours. The incidence of sensitization was 5/5 and severity was 2.0 at
24 hours, 1.1 at 48 hours and 1.0 at 72 hours.
Naive positive control group: After the challenge application of the
positive control article, no dermal irritation was observed for any of
Tables see under attached full study report
Methacrylic acid was tested in a Modified Bühler test (version 1981) in
20 male Guinea pigs. Based on the results of a range finding test and
observations during the main test first induction was performed with 0.4
ml 20 % methacrylic acid in deionized water. Second and third experiment
has been performed due to skin reactions in the first experiment at
concentrations of 15 % MAA in deionized water. Challenge has been
performed 14 days after third induction with 10 % methacrylic acid in
Methacrylic acid is not a dermal sensitizer in albino guinea pigs.
The positive control, 1-chloro-2,4-dinitrobenzene, when induced and
challenged as an 0.1 % w/v concentration in a 50% ethanol: 0.9% saline
solution is a skin sensitizer in albino guinea pigs.
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