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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Published data

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Use of Mathematical Models in the Study of Structure-Toxicity|Relationship of Dental Compounds: I. Esters of Acrylic and|Methacrylic Acids
Author:
Lawrence W.H., Bass G.E., Purcell W.P., Autian J.
Year:
1972
Bibliographic source:
J. Dental. Res. 51(2): 526-535 (1972)
Reference Type:
publication
Title:
Toxicological and Pharmacological actions of methacrylate monomers. I. Effects on isolated, perfused rabbit heart.
Author:
Mir GN, Lawrence WH, Aution J
Year:
1973
Bibliographic source:
J. Pharm. Sci. 62: 778-782

Materials and methods

Principles of method if other than guideline:
other: 10 mice / dose group (male albino ICR mice), observation time: 7 days; LD50 -dose was calculated by the Cornfield-Mantel modification of Karber's method (1950)
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
MAA contained from 5-2,0 ppm of the polymerization inhibitor, monomethyl ether of hydroquinone or 100 ppm hydroquinone

Test animals

Species:
mouse
Strain:
other: ICR
Sex:
male

Administration / exposure

Route of administration:
intraperitoneal
No. of animals per sex per dose:
10 mice / dose group
Details on study design:
7 day observation period
Statistics:
LD50 -dose was calculated by the Cornfield-Mantel modification of Karber's method (1950)

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
0.048 other: ml/kg

Applicant's summary and conclusion