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EC number: 204-694-8
CAS number: 124-28-7
An in vivo micronucleus test was carried in NMRI mice with the test
substance according to OECD guideline 474. The test compound was
dissolved in sesame oil and was given twice at an interval of 24 hours
as oral doses of 0, 120, 400 and 1200 mg per kg body weight to male and
female mice, based on the results of a previous dose range finding
assay. According to the test procedure the animals were killed 24 hours
Oral administration of 1200 mg substance per kg body weight resulted in
the death of six out of ten animals treated. These animals were replaced
and survived after treatment. The following signs of toxicity were
observed: decreased motor activity, diarrhea, palpebral fissure narrow,
uncoordinated movements, stupor, tonic convulsions and prone position.
24 hours after application all animals were free of clinical signs of
toxicity. The dissesction of the animals revealed no test subtance
related findings. The bone marrow smears were examined for the
occurrence of micronuclei in red blood cells. No increase in the
incidence of micronucleated polychromatic erythrocytes in treated groups
in comparison to control group. The ratio of polychromated erythrocytes
to total erythrocytes decreased in the highest dose group: 20% of
control value. Under the conditions of the present study the substance
is not mutagenic.
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