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EC number: 204-694-8
CAS number: 124-28-7
Six New Zealand rabbits were treated with the test substance in an
dermal irritation/corrosion study according to guidelines OECD 404 and
EU B.4. The test substance produced erythema with a mean score of 2 and
edema with a mean score of 2.2. After 4 h of exposure, severe
dermal responses were produced. The adverse skin reactions sometimes
precluded accurate evaluation of erythema and oedema. The reactions were
identified as well-defined erythema, severe oedema, haemorrhage of the
dermal capillaries, a brown discolouration of the epidermis, blanching
of the skin, white raised areas of skin, scabbing, loss of skin
elasticity, a dry straw-coloured crust (possible hyperkeratinisation),
thickening of the skin, reduced re-growth of fur and glossy skin. Scar
tissue, indicative of dermal corrosion was noted in five rabbits. Under
the conditions of this study the test material was corrosive to the skin
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