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EC number: 204-694-8
CAS number: 124-28-7
The eye-irritating properties were examined in a test according to
guideline OECD 405 and EU B.5. 0.1 mL of the test substance were applied
to the left eye of one New Zealand white rabbit. The untreated eye
served as internal control. Effects were evaluated 1 h (after removing
the test substance by washing with warm physiological saline), 24, 48
and 72 hours post application and on day 7 and 14.
The iris of the treated eye was reddened 1 h post application. A
colourless discharge was also observed at this time point. The
conjunctiva showed swelling up to 72 h, with half closed or more than
half closed lids, hyperaemia of blodd vessels to a diffuse crimson
discolouration. Eschar formation was observed on the skin around the eye
at >/= 72 h post application, after 7 to 14 days approx. 2 cm of the
surrounding area, accompanied by hardening of the skin and total hair
loss at the end of the study. After detaching of eschar the skin showed
a pergament-like, coarsely porous appearance. The hair roots seemed to
be irreversibly damaged. Fluorescein staining revealed no opacity of the
cornea. Due to the severe effects on the skin surrouunding the eye,
these results were interpreted as irreversible damage.
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