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EC number: 204-694-8
CAS number: 124-28-7
In a reproduction/ development toxicity screening test
according to OECD guideline 421 the test subatance was administered
orally via gavage to male and female Sprague -Dawley rats. 14 days prior
to mating and for the female rats until day four after delivery animals
were treated with 0, 50, 150 , 300 or 450 mg/kg bw/day. Under the test
conditions the no-observed-effect level (NOEL) for both parent animals
and their pups was 50 mg test item/ kg b.w./day, by gavage. 150 mg/kg
b.w./day were in the beginning lethal range for pregnant rats and in the
toxic range for embryos/fetuses/pups. It can be concluded that effects
in pubs were a consequence of maternal toxicity and not directly related
to the applied substance. Only one dam of the group treated with 300
mg/kg b.w./day delivered one female pup alive. Reproduction
was not affected except at already lethal concentrations.
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