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EC number: 204-694-8
CAS number: 124-28-7
In five reliable studies (3x RL 1, 2x RL 2) with different members of the DMA category, determined EC50 (3 h) values were between 13 mg/L (C12-18 DMA; RL 1) and 80 mg/L (C12-14 DMA; RL 2).
Reliable (RL 1 for C10, C12-18, and C16-18 DMA; RL 2 for C12-14
and C16 DMA) Activated Sludge Respiration Inhibition tests were
performed according to OECD 209 meeting the validity criteria of the
OECD-guideline. RL 1 studies are GLP-compliant. The resultingEC50 (3
h) values were 32.6 mg/L for C10, 80 mg/L for C12-14, 40 mg/L for C16,
13 mg/L for C12-18 and 38 mg/L for C16-18 DMA. Further, three
non-reliable studies (RL 3) are available reporting EC50 values between
>1000 mg/L for C18 DMA and 27.3 mg/L for C12 DMA. In most studies, EC10
values could not be determined. No obvious relationship between chain
length and toxicity exists.
Thus, the decisive value for derivation of a PNECSTP
microorgfor the DMA category will be EC50 (3 h) determined with
C12-18 DMA of 13 mg/L.
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