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Toxicity to microorganisms

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Description of key information

In five reliable studies (3x RL 1, 2x RL 2) with different members of the DMA category, determined EC50 (3 h) values were between 13 mg/L (C12-18 DMA; RL 1) and 80 mg/L (C12-14 DMA; RL 2). 

Key value for chemical safety assessment

EC50 for microorganisms:
13 mg/L

Additional information

Reliable (RL 1 for C10, C12-18, and C16-18 DMA; RL 2 for C12-14 and C16 DMA) Activated Sludge Respiration Inhibition tests were performed according to OECD 209 meeting the validity criteria of the OECD-guideline. RL 1 studies are GLP-compliant. The resultingEC50 (3 h) values were 32.6 mg/L for C10, 80 mg/L for C12-14, 40 mg/L for C16, 13 mg/L for C12-18 and 38 mg/L for C16-18 DMA. Further, three non-reliable studies (RL 3) are available reporting EC50 values between >1000 mg/L for C18 DMA and 27.3 mg/L for C12 DMA. In most studies, EC10 values could not be determined. No obvious relationship between chain length and toxicity exists.

Thus, the decisive value for derivation of a PNECSTP microorgfor the DMA category will be EC50 (3 h) determined with C12-18 DMA of 13 mg/L.