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EC number: 203-308-5
CAS number: 105-55-5
Experimental toxicokinetic studies were not available. However, as per REACH guidance document R7.C (May 2008), information on absorption, distribution, metabolism and excretion may be deduced from the physicochemical properties. Indeed, DETU seems to be well absorbed by oral and dermal route, then well distributes in the body and probably excreted in urines.
The following remarks on the toxicokinetics of DETU are based on
the available studies. Experimental toxicokinetic studies were not
available. However, as per REACH guidance document R7.C (May 2008),
information on absorption, distribution, metabolism and excretion may be
deduced from the physicochemical properties, including:
-Molecular weight: 132.23 g/mol
-Water solubility: 42 g/L (20°C), DETU is highly soluble in water.
-Partition coefficient Log Kow: 0.57
-Vapour pressure: 0.00065 Pa (25°C)
The physicochemical characteristics of DETU (log Kow 0.57) and the
molecular mass (132.23 g/mol) are in the range suggestive of absorption
from the gastro-intestinal tract subsequent to oral ingestion (with a
molecular weight below 500, and a log Kow between -1 and 4). This
assumption of an oral absorption is confirmed by the data acute oral
toxicity (LD50 = 930 mg/kg bw in mice).
Molecular weight (near to 100 g/mol) is in ranges which favour
dermal absorption. This assumption of a dermal absorption is confirmed
by the skin sensitisation data as DETU is a skin sensitizer.
DISTRIBUTION and METABOLISM
As a small molecule a wide distribution of DETU is expected. This
assumption is confirmed by the changes shown in the repeated dose
toxicity studies following oral application: effects on thyroid were
specific to the oral administration of DETU in rats.
No specific information was found on metabolism of DETU.
DETU is probably excreted in the urine, because it is a
water-soluble substance with a low molecular weight (below 300); and
generally, they are conjugated metabolites from Phase II
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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