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EC number: 203-308-5
CAS number: 105-55-5
Tables : Eye irritation test
Region of eye
Description of ocular reactions
Mean irritation score (1)
of scores on days 2, 3 and 4
* : none
U: fluorescein batch No.D616
/: fluorescein not used
S: Whitish purulent discharge
My = myosis
ocular examination not performed
The potential of the test substance DETU
(DIETHYL THIOUREE) to induce ocular irritation was evaluated in rabbits
according to OECD (No. 405, 24th February 1987) and EC (92/69/EEC, B.5,
31st July 1992) guidelines, and in compliance with the principles of
Good Laboratory Practice Regulations.
A single dose of 100 mg of the test
substance in its original form was introduced into the left conjunctival
sac of three male New Zealand White rabbits. The right eye was not
treated and served as control. The eyes were not rinsed after
administration of the test substance. Ocular reactions were observed
approximately 1 hour, 24, 48 and 72 hours after the administration and
then daily until the end of the observation period. The mean values of
the scores for chemosis, redness of the conjunctiva, iris lesions and
corneal opacity were calculated for each animal.
Very slight to moderate conjunctival
reactions (very slight to moderate chemosis, very slight to moderate
redness of the conjunctiva and clear to whitish purulent discharge) were
observed in all animals from day 1: some of these reactions persisted up
to day 8 or 9, or up to the end of the observation period (day 22) in
A slight iritis was noted in all animals on
day 1; it persisted up to day 4 (two animals) or 6.
A very slight or slight corneal opacity was
recorded in all animals from day 2; it persisted up to day 7 or 9, or up
to the end of the observation period (day 22) in one animal. A myosis
was noted in this last animal between days 14 to 17.
Mean scores calculated for each animal over
24, 48 and 72 hours were 2.3, 3.0 and 2.3 for chemosis, 3.0, 3.0 and 3.0
for redness of the conjunctiva, 1.0, 1.0 and 1.0 for iris lesions and
2.0, 2.0 and 2.0 for corneal opacity.
Under these experimental conditions, the
test substance DETU (DIETHYL THIOUREE) is severely irritant when
administered by ocular route to rabbits.
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