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EC number: 203-308-5
CAS number: 105-55-5
Table of results: Comet assay (in vivo)
Tail length (µm)
Control (distilled water)
DETU (158 mg/kg)
Values are mean +/- SD.
*: the comparison between treated and control rats given the same
vehicle used to dissolve the test compound was performed by means of
ANOVA; significant difference (p<0.05).
DETU was administered p.o. in rats in a single dose corresponding to 1/2
LD50 (= 158 mg/kg bw). Rats were sacrified for the evaluation of DNE
fragmentation 16h after treatment. None rats died or showed marked signs
of toxicity. DETU induced in thyroid cells a statistically significant
marked increase of DNA lesions, the ratio treated/control of tail lenght
being 8.6 (ETU).
DNA fragmentation was absent or of minimum degree in both liver and
kidney of rats treated with DETU that in rats caused only the
development of thyroid tumors.
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