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EC number: 203-308-5
CAS number: 105-55-5
The only available data with DETU on humans are sensitisation data.DETU is a skin sensitizer and several cases of allergic contact dermatitis were observed and described in publications. The most interessant publication is this of Liippo (2010) because it's a more recent publication and 15 100 patients were analyzed.
Thioureas are widely used accelerators in the manufacture of synthetic
rubber products. Allergic contact dermatitis because of thiourea
sensitization from orthopaedic joint braces, protective clothing, swim
suits, and various sports equipment has benn reported.
Because the occurrence of rubber products containing thioureas may be
common today, a mixture of three thiourea chemicals was added to the
Finnish patch test baseline series in 2002 (Liippo 2010). Also, the
authors have analyzed the occurrence of positive patch test reactions to
thiourea chemicals and sources of sensitization among Finnish general
dermatology patients with suspected contact allergy during a 6 -year
period. Thiourea mix yielded positive patch test reactions in 59 of
15100 patients (0.39%). Diethylthiourea was positive in 24/33 patients
tested with individual rubber chemicals.
A more recent publication (Dall ABH et al. 2012) evaluated the
occurrence of sensitisation to DETU during a 19 -year period using data
from the Allergen Bank database at the Department of Dermatology and
Allergy Center (Odense University Hospital). PA total of 239 patients
were patch tested with DETU 1% in petrolatum obtained from the Allergen
Bank. One hundred and fifty-one patients were tested by 27 different
dermatologists in private practice, and positive reactions were found in
16% (24/151) of the patients. Eighty-eight patients were tested at the
dermatology department and positive reactions were found in 15% (13/88).
Thus, 15% (37/239) had positive patch test reactions to DETU, all with
current clinical relevance and all strong. DETU 1% pet is a contact
allergen giving a high yield of strongly positive clinically relevant
patch test reactions following targeted testing in patients with a
history of neoprene rubber dermatitis.
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