Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-308-5
CAS number: 105-55-5
DETU was tested in rats for capacity to interfere with the endocrine
function of the thyroid gland. Test substance was administered to young
rats by mixing it with the food at 37 mg/kg bw. At the end of ten days
the thyroid glands were examined grossly and microscopically for
evidence of hypertrophy and hyperplasia, and the relative activities of
the compounds were then roughly compared on the basis on the minimal
dose required to produce a noticeable effect.
The weight of thyroid was increased in rat treated with DETU compared to
control rats. Thyroid iodine concentration in treated rats was smaller
than concentration of control rats. Therefore, an antithyroid activity
of DETU was observed in the rats treated with DETU compared to the
control rats (treated with thiouracil).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again