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EC number: 203-782-3
CAS number: 110-60-1
Ethylenediamine dihydrochloride (EDA • 2HC1) was incorporated in the
diet of Fischer 344 rats at dosage goals of 0.50, 0.15, 0.05, or 0
g/kg/day in a two-generation reproduction study. The parent generation
(Fo) and the F1 generation were each bred once.
Parameters examined included indices of fertility, gestation of dams,
gestation survival, 0- to 4-, 4- to 14- and 4- to 21-day survival of
pups, number of pups born alive, and number of pups weaned per litter.
Furthermore, observations were made on mortality, diet consumption, and
body weight of the adult rats in Fo and F, generation. Randomly selected
F, weanlings and adults and F2 weanlings were sacrificed and organ
weights were obtained; in addition, gross and histologic examinations
were conducted on these rats. No reproductive toxicity was observed
in this study. Some effects were observed in both sexes for the Fo
and F1 parent rats. These effects were mainly associated with the high
dosage level and included reduction of body weight gain and changes in
liver (decrease) and kidney (increase) weights in the adult rats. The
only microscopic lesion observed was hepatocellular pleomorphism in the
high level F, adult males and females; a greater prevalence and severity
of this lesion was seen in the female rats.
NOAEL = 150 mg/kg/day (mating after 100 days of exposure)
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