Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

Read across studies with Ethylenediamine and Hexamethylenediamine show fast metabolisation, the primary route of excretion is in the urine. 
N-acetylation is a major metabolic pathway for EDA in the rat. In the urine, AcEDA accounts for approximately half of the radioactivity. The data on the ion-exchange chromatography of aqueous fecal extract also revealed the presence of AcEDA as a major metabolite. In addition to acetylation, the enzymatic formation of aminoacetaldehyde from EDA as suggested by Hoshika (1967) is highly probable in the rat. If this reaction happens in vivo, it is conceivable that CO2 might be generated from ethanolamine, a probable metabolite of aminoacetaldehyde, through a series of reactions as discussed by Taylor and Richardson (1967).
1,6 Hexamethylene diamine: Biotransformation of primary amino group by acetylation by acetylcoenzyme A dependent N-acteyltransferase leads to the formation of monoacetylated 1,6-Hexanediamine. More than 90% is excreted via urine within 10 hours.

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information